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0716719819 (hardback) |
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QH581.2 |
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.D37 19902 |
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571.6 D251m 1990 |
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220 |
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Darnell, James E. |
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| 245 #0 - TITLE STATEMENT |
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Molecular cell biology / |
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James Darnell, Harvey Lodish, David Baltimore. |
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6 |
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Second edition. |
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| Place of production, publication, distribution, manufacture |
New York : |
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| Name of producer, publisher, distributor, manufacturer |
Scientific American Books :;Distributed by W.H. Freeman, |
| Date of production, publication, distribution, manufacture, or copyright notice |
[1990];copyright 199046 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Accompanying material |
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| Dimensions |
28 cm. |
| Extent |
xl, 1105 pages : |
| Other physical details |
illustrations (some color) |
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text |
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56 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
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Includes bibliographical references and index. |
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| 505 ## - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
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Introduction: The history of molecular cell biology. Evolution and the cell theory -- Classical biochemistry and genetics -- The merging of genetics and biochemistry -- The birth of molecular biology -- A modern view of cell structure -- Part I. Molecules, cells, proteins, and experimental techniques: a primer. [Ch.1] Chemical foundations -- Energy -- Chemical bonds -- Chemical equilibrium -- Ph and the concentration of hydrogen ions -- The direction of chemical reactions -- Activation energy and reaction rate -- [Ch.2] Molecules in cells proteins -- Enzymes -- Antibodies -- Nucleic acids -- DNA -- Lipids and biomembranes -- Carbohydrates -- The primacy of proteins -- [Ch.3] Synthesis of proteins and nucleic acids -- Rules for the synthesis of proteins and nucleic acids -- Protein synthesis: the three roles of RNA -- The steps in protein synthesis -- Nucleic acid synthesis -- [Ch.4] The study of cell organization and subcellular structure -- Prokaryotic and eukaryotic cells -- Light microscopy and cell architecture -- Electron microscopy -- Sorting cells and their parts -- The organelles of the eukaryotic cells -- [Ch.5] Growing and manipulating cells and viruses -- Types of cell division -- The cell cycle in prokaryotes consists of DNA replication followed immediately by cell division -- Eukaryotic DNA synthesis occurs in a special phase of the cell cycle -- The growth of microorganisms and cells in culture -- Cell fusion: an important technique in somatic-cell genetics -- DNA transfer into eukaryotic cells -- Viruses: structures and function.;[Ch.6] Manipulating macromolecules -- Radioisotopes: the indispensible modern means of following biological activity -- Determining the size of nucleic acids and proteins -- Examining the sequences of nucleic acids and proteins -- Recombinant DNA: selection and production of specific DNA -- Controlled deletions and base-specific mutagenesis of DNA -- Synthetic peptide and nucleotide sequences: their use in isolating and identifying genes -- Part II. Gene expression, structure, and replication -- [Ch.7] RNA synthesis and gene control in prokaryotes -- Overall strategy of prokaryotic gene control -- Control of transcriptional initiation -- Negative control of transcription: the lactose operon -- Positive control of transcription: the arabinose operon -- Compound control of transcription -- Control of regulatory proteins -- Control of transcriptional termination -- Bacteriophage a infection: alternative physiologic states determined by a complex transcriptional control program -- Global control in E. Coli -- Stability of biopolymers in bacterial cells -- [Ch.8] RNA synthesis and processing in eukaryotes -- Relationship of nuclear and cytoplasmic RNA -- Function and structure of RNA polymerases -- Three methods for mapping transcription units -- Synthesis and processing of Pre-rRNA -- Synthesis and processing of 5S rRNA and tRNAs -- Synthesis and processing of mRNAs: general pathway -- Transcription of mRNA genes by RNA polymerase II -- Conversion of hnRNA to mRNA -- Variations on the splicing theme, including self-splicing -- mRNAs may be directed toward specific cytoplasmic sites.;[Ch.9] The structure of eukaryotic chromosomes -- Morphology and functional elements of eukaryotic chromosomes -- Structure of chromatin -- Biologic definitions of a gene -- Molecular definition of a gene -- [Ch.10] Eukaryotic chromosomes and genes: molecular anatomy -- Major classes of eukaryotic DNA -- Solitary protein-coding genes -- Duplicated protein-coding genes -- Tandemly repeated genes encoding rRNA, tRNA, and histones -- Repetitious DNA fractions -- Simple-sequence DNA -- Intermediate repeat DNA and mobile DNA elements -- Functional rearrangements in chromosomal DNA -- [Ch.11] Gene control and the molecular genetics of development in eukaryotes -- The purpose of gene control in unicellular versus multicellular organisms -- Variations in proteins among cell types -- The three components of gene control: signals, levels, and mechanisms -- Signals for gene control -- Experimental demonstration of transcriptional control -- Structure and function of DNA-binding proteins that regulate transcription of protein-coding genes -- Transcriptional control of yeast cell specificity -- Gene control in animal cells -- Control of regulatory-protein activity and possible effects of chromatin structure on gene activity -- Control of transcriptional termination -- Differential processing of pre-mRNA -- Overlapping transcription units: transcriptional control not processing control -- Regulation of ribosomal RNA -- Cytoplasmic control of gene expression.;[Ch.12] DNA replication, repair, and recombination -- General features of DNA synthesis and replication -- Initiation and propagation of a DNA chain at a growing fork -- Topoisomerases and superhelicity in DNA -- Assembly of DNA into nucleosomes -- Repair of DNA -- Recombination between homologous DNA sites -- Part III. Cell structure and function -- [Ch.13] The plasma membrane -- The architecture of lipid membranes -- Membrane proteins -- Principles of membrane organization -- The erythrocyte membrane: cytoskeletal attachment -- Specialized regions of the plasma membrane -- Types of cell junctions -- [Ch.14] Transport across cell membranes -- Passive transport across the cell membrane -- Ion channels, intracellular ion environment, and membrane electric potential -- Active ion transport and ATP hydrolysis -- Cotransport: symport and antiport -- Transport into prokaryotic cells -- Osmosis, movement of water, and the regulation of cell volume -- The internalization of macromolecules and particles -- Receptor-mediated endocytosis -- Entry of viruses and toxins into cells -- [Ch.15] Energy conversion: the formation of ATP in mitochondria and bacteria -- Energy metabolism in the cytosol -- Mitochondria and the metabolism of carbohydrates and lipids -- The proton-motive force, ATP generation, and transport of metabolite closed vesicles are required for the generation of ATP -- NADH, electron transport, and proton pumping -- Metabolic regulation --;[Ch.16] Photosynthesis -- An overview of photosynthesis in plants -- The light-absorbing steps of photosynthesis -- Molecular analysis of bacterial photosynthesis -- The structure and function of the two plant photosystems: PSI and PSII -- CO2 metabolism during photosynthesis -- [Ch.17] Plasma-membrane, secretory, and lysosome proteins: biosynthesis and sorting -- The synthesis of membrane lipids -- Sites of organelle- and membrane-protein synthesis -- Overall pathway for the synthesis of secretory and membrane proteins -- The transport of secretory and membrane proteins into or across the ER membrane -- Posttranslational modifications of secretory and membrane proteins in the rough -- Golgi vesicles: sorting and glycosylation of secretory and membrane proteins -- Golgi and post-golgi sorting and processing of secretory and membrane proteins -- [Ch.18] Organelle biogenesis: the nucleus, chloroplast, and mitochondrion -- Assembly and disassembly of the nuclear membrane -- Protein import into the cell nucleus -- Mitochondrial DNA: structure, expression, and variability Synthesis and localization of mitochondrial proteins -- Chioroplast DNA and biogenesis of plastids -- [Ch.19] Cell-to-cell signaling: hormones and receptors -- The role of extracellular signals in cellular metabolism -- Identification and purification of cell- surface receptors -- Epinephrine receptors and the activation of adenylate cyclase -- cAMP and regulation of cellular metabolism -- Ca2+ ions, inositol phosphates, and 1,2- diacylglycerol as second messengers -- Insulin and glucagon: hormone regulation of blood glucose levels -- Receptor regulation -- Hormones and cell-to-cell signaling in microorganisms -- Plant hormones and plant growth and differentiation.;[Ch.20] Nerve cells and the electric properties of cell membranes -- Neurons, synapses, and nerve circuits -- The action potential and conduction of electric impulses -- Molecular properties of voltage-gated ion channel proteins -- Synapses and impulse transmission -- Synaptic transmission and the nicotinic acetylcholine receptor -- Functions of other neurotransmitters and their receptors -- Memory and neurotransmitters -- Sensory transduction: the visual system -- [Ch.21] Microtubules and cellular movements -- Structure and diversity of microtubules -- Structural and kinetic polarity of microtubules -- |
| 505 ## - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
Heterogenity of a- and b-tubulin -- Intracellular transport via microtubules -- Cilia and flagella: structure and movement -- Basal bodies and centrioles: structure and properties -- Function of microtubules in mitosis -- [Ch.22] Actin, myosin, and intermediate filaments: cell movements and cell shape -- Actin and myosin filaments -- Muscle structure and function -- Actin and myosin in nonmuscle cells -- Intermediate filaments -- [Ch.23] Multicellularity: cell-cell and cell-matrix interactions -- The extracellular matrix serves many functions -- Collagen: a class of multifunctional fibrous proteins -- Hyaluronic acid and proteoglycans -- Laminin, fibronectin, and other multiadhesive matrix glycoproteins -- Cell-cell adhesion proteins -- Cell and matrix interactions during development -- Cell and matrix interactions during neuron development -- Structure and function of the plant cell wall -- Part IV. The new biology: facing classic questions at the frontier.;[Ch. 24] Cancer characteristics of tumor cells -- Use of cell cultures in cancer research -- DNA viruses as transforming agents -- RNA-containing retroviruses as transforming agents -- Human tumor viruses -- Chemical carcinogens -- The role of radiation and DNA repair in carcinogenesis -- Oncogenes and their proteins: classification and characteristics -- The role of cellular oncogenes in carcinogenesis -- The multicausal, multistep nature of carcinogenesis -- Human cancer -- [Ch.25] Immunity -- Overview -- Antibodies and the generation of diversity -- The antigen-independent phase of b-lymphocyte maturation T lymphocytes -- The antigen-dependent phase of the immune response -- [Ch.26] Evolution of cells -- Prebiotic synthesis -- RNA catalysis: a basis for a precellular genetic system? -- A reconstructive analysis of cell lineages -- Evolution of gene structure: lessons from present-day intron distributions. |
| -- |
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| 506 ## - RESTRICTIONS ON ACCESS NOTE |
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5 |
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| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
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<a href=""></a> |
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| 540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE |
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| Terms governing use and reproduction |
5 |
| 542 ## - INFORMATION RELATING TO COPYRIGHT STATUS |
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| 546 ## - LANGUAGE NOTE |
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| Title of a work |
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2 |
| Fuller form of name |
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0 |
| Geographic subdivision |
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| 610 ## - SUBJECT ADDED ENTRY--CORPORATE NAME |
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2 |
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| 630 ## - SUBJECT ADDED ENTRY--UNIFORM TITLE |
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| 648 ## - SUBJECT ADDED ENTRY--CHRONOLOGICAL TERM |
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| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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Cytology.;Molecular biology.;Cells.;Molecular Biology. |
| Active dates |
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20 |
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20 |
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| 655 ## - INDEX TERM--GENRE/FORM |
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| Title of a work |
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| Numeration |
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| Version |
1 |
| Fuller form of name |
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| Date of a work |
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40 |
| Name of part/section of a work |
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| Dates associated with a name |
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| Relator term |
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| Personal name |
Lodish, Harvey F.;Baltimore, David. |
| Language of a work |
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| Number of part/section of a work |
6 |
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| Date of a work |
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40 |
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| Date of meeting or treaty signing |
5 |
| Language of a work |
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6 |
| Corporate name or jurisdiction name as entry element |
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| 711 ## - ADDED ENTRY--MEETING NAME |
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| Meeting name or jurisdiction name as entry element |
|
| -- |
|
| Date of meeting or treaty signing |
|
| Number (BK CF MP MU SE VM MX) [OBSOLETE] |
|
| Number of part/section/meeting |
|
| Title of a work |
|
| Location of meeting |
|
| 730 ## - ADDED ENTRY--UNIFORM TITLE |
|---|
| Version |
|
| -- |
|
| Uniform title |
|
| Date of treaty signing |
|
| Number of part/section of a work |
|
| Name of part/section of a work |
|
| Date of a work |
|
| Language of a work |
|
| Form subheading |
|
| 740 ## - ADDED ENTRY--UNCONTROLLED RELATED/ANALYTICAL TITLE |
|---|
| -- |
|
| -- |
|
| Uncontrolled related/analytical title |
|
| -- |
|
| -- |
|
| Number of part/section of a work |
|
| -- |
6 |
| 753 ## - SYSTEM DETAILS ACCESS TO COMPUTER FILES |
|---|
| Operating system |
|
| -- |
|
| Make and model of machine |
|
| 767 ## - TRANSLATION ENTRY |
|---|
| Title |
|
| -- |
|
| Record control number |
|
| 770 ## - SUPPLEMENT/SPECIAL ISSUE ENTRY |
|---|
| Title |
|
| -- |
|
| Record control number |
|
| International Standard Serial Number |
|
| 773 ## - HOST ITEM ENTRY |
|---|
| Main entry heading |
|
| -- |
|
| Place, publisher, and date of publication |
|
| Related parts |
|
| Material-specific details |
|
| Title |
|
| Edition |
|
| -- |
|
| Relationship information |
|
| Abbreviated title |
|
| 775 ## - OTHER EDITION ENTRY |
|---|
| Title |
|
| -- |
|
| Record control number |
|
| International Standard Serial Number |
|
| 776 ## - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Uniform title |
|
| -- |
|
| Main entry heading |
|
| Place, publisher, and date of publication |
|
| Edition |
|
| International Standard Book Number |
|
| Relationship information |
|
| Title |
|
| International Standard Serial Number |
|
| Physical description |
|
| Qualifying information |
|
| Record control number |
|
| 780 ## - PRECEDING ENTRY |
|---|
| International Standard Serial Number |
|
| -- |
|
| Main entry heading |
|
| Related parts |
|
| Title |
|
| Record control number |
|
| 785 ## - SUCCEEDING ENTRY |
|---|
| Title |
|
| -- |
|
| Record control number |
|
| Main entry heading |
|
| International Standard Serial Number |
|
| 787 ## - OTHER RELATIONSHIP ENTRY |
|---|
| International Standard Serial Number |
|
| -- |
|
| Place, publisher, and date of publication |
|
| Related parts |
|
| Relationship information |
|
| Title |
|
| Record control number |
|
| 800 ## - SERIES ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
|
| -- |
|
| Dates associated with a name |
|
| Language of a work |
|
| Date of a work |
|
| Title of a work |
0 |
| Fuller form of name |
|
| Volume/sequential designation |
|
| 810 ## - SERIES ADDED ENTRY--CORPORATE NAME |
|---|
| Corporate name or jurisdiction name as entry element |
|
| -- |
|
| Subordinate unit |
|
| Date of a work |
|
| Title of a work |
|
| -- |
|
| Volume/sequential designation |
|
| 830 ## - SERIES ADDED ENTRY--UNIFORM TITLE |
|---|
| International Standard Serial Number |
|
| -- |
|
| Uniform title |
|
| Name of part/section of a work |
|
| Number of part/section of a work |
|
| Language of a work |
0 |
| Volume/sequential designation |
|
| 942 ## - ADDED ENTRY ELEMENTS |
|---|
| Institution code [OBSOLETE] |
|
| -- |
lcc |
| Item type |
Book |