| 000 -LEADER |
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| fixed length control field |
02927nam a22002417a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
FT8809 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20251120122336.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
251120b ||||| |||| 00| 0 eng d |
| 041 ## - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
engtag |
| 050 ## - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
TP155 D36 2024 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
. |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Danzil, Michael Francis A.; Gabas, Ynac Catherine D.; Jaurigue, John Philip D.; Liwag, Ernest Lance Nixon R.; Marcos, Caroline P. |
| 245 ## - TITLE STATEMENT |
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| Title |
Synthesis of keratin-hyaluronic acid hydrogel film for sustained-release of gentamicin |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
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| Place of production, publication, distribution, manufacture |
. |
| Name of producer, publisher, distributor, manufacturer |
. |
| Date of production, publication, distribution, manufacture, or copyright notice |
c2024 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Other physical details |
Undergraduate Thesis: (Bachelor of Science in Chemical Engineering) - Pamantasan ng Lungsod ng Maynila, 2024 |
| 336 ## - CONTENT TYPE |
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. |
| Content type term |
text |
| Content type code |
. |
| 337 ## - MEDIA TYPE |
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. |
| Media type term |
unmediated |
| Media type code |
. |
| 338 ## - CARRIER TYPE |
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| Source |
. |
| Carrier type term |
volume |
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. |
| 505 ## - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
ABSTRACT: Skin infection treatment can be achieved through topical drug delivery systems incorporated with antibiotics. To address the problem of antibiotic resistance, employing sustained release of drug from its drug carrier such as hydrogel films are observed to be a potential material to use. Natural polymers such as keratin are continuously studied as a hydrogel material, however, it lacks enough mechanical integrity on its own. Hence, this study synthesized keratin and hyaluronic acid (K-HA)-based hydrogel film infused with gentamicin in achieve sustained release delivery of the drug. The K-HA hydrogel film was synthesized via the carbodiimide-mediated crosslinking method which formed amide covalent crosslinks to create the polymer matrix. The presence of amide crosslinks was confirmed through the results of FTIR spectroscopy. The K-HA hydrogel film was then tested for its tensile modules, elongation, swelling capacity, and drug release kinetics. The result showed that tensile modules had increased as the amount of keratin decreased which was the opposite for the elongation. The 75-25 K-HA ratio has highest tensile modulus of 0.728 while the 100:0 K-HA ratio has 78.47% elongation. The K-HA ratio significantly influences the tensile modulus and elongation. On the other hand, the K-HA ratio is not significant with the swelling capacity with the highest value observed in 75:25 K-HA. The closest to the optimal formulation with respect to the physical properties among hydrogel films in the ratio of 75:25 K-HA. Lastly, the drug release kinetics of K-HA hydrogel film were modelled using various kinetic models. The model that shows the best fit and has the highest coefficient of determination (R2) is Korsmeyer-Peppas, suggesting that it most accurately describes the Fickian drug release mechanism of gentamicin in K-HA hydrogel film. It is followed by Weibull, zero-order, and first-order models, indicative of the sustained release of gentamicin. Overall, this study successfully achieved synthesizing a keratin-hyaluronic acid-based hydrogel film for sustained release of gentamicin. |
| 526 ## - STUDY PROGRAM INFORMATION NOTE |
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| Classification |
Filipiniana |
| 655 ## - INDEX TERM--GENRE/FORM |
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| Genre/form data or focus term |
academic writing |
| 942 ## - ADDED ENTRY ELEMENTS |
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| Source of classification or shelving scheme |
|
| Item type |
Thesis/Dissertation |