Anti-angiogenic potential of sacccharum spontanuem (Talahib) leaf enthanolic extract via chlotiosllantoic membrane (CAM) assay 6

By: Bautista, Angelica Mae H.; Lawan, Mary Justine Mae I.; Manzano, Julianne Kaye A.; Pedro, Jann Matthew A.; Pilimpinas, Sittie Alexandria C. 4 0 16, [, ] | [, ] |
Contributor(s): 5 6 [] |
Language: Unknown language code Summary language: Unknown language code Original language: Unknown language code Series: ; 4544446Edition: Description: 219 pagesContent type: text Media type: unmediated Carrier type: volumeISBN: ISSN: 2Other title: 6 []Uniform titles: | | Related works: 1 40 6 []Subject(s): -- 2 -- 0 -- -- | -- 2 -- 0 -- 6 -- | 2 0 -- | -- -- 20 -- | | -- -- -- -- 20 -- | -- -- -- 20 -- --Genre/Form: -- 2 -- Additional physical formats: DDC classification: | LOC classification: | | 2Other classification:
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Action note: In: Summary: ABSTRACT: This study evaluated the antiangiogenic potential of Saccharum spontaneum (Talahib) leaf ethanolic extract using the Duck Chorioallantoic Membrane (CAM) assay, addressing the need for alternative natural therapies in angiogenesis-related diseases such as cancer. The positive control, 10 µg/mL of Ehretia microphylla (Tsaang-gubat), demonstrated a strong anti-angiogenic effect, followed by the highest dose (100% of the LC50) of the Talahib extract, while lower concentrations had weaker effects. For Average Blood Vessel Diameter (Dv), the positive control had the least value at 11.67 ± 0.97 mm, followed by the 100% concentration showing a trend of decreasing diameter with increasing concentration. The Total Blood Vessel Length (LT) saw the greatest reduction at the 75% concentration (3923.82 ± 844.99 pixels), indicating that the response is not directly proportional to concentration. Statistical analysis of LT % inhibition revealed significant differences between all concentrations of the Talahib extract and the negative control. Significant differences were also noted between the 50% and 75% groups, and between the 75% group and the positive control. The 75% concentration, identified as the most effective, likely showed significant differences in LT and LT % inhibition compared to the positive control. Phytochemical analysis confirmed the presence of bioactive compounds in the extract, supporting its anti- angiogenic potential. These results indicate that Talahib leaf ethanolic extract. particularly at the 75% concentration, exhibits notable antiangiogenic potential, with a more pronounced effect on reducing total blood vessel length rather than blood vessel diameter. Keywords: Anti-angiogenesis, cancer, plant extract, chorioallantoic membrane assay, leaf, Saccharum spontaneum Other editions:
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Filipiniana Section 		Filipiniana-Thesis QH581 B38 2024 (Browse shelf) Available FT8466
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Undergraduate Thesis: (BS Biology major in Medical Biology) - Pamantasan ng Lungsod ng Maynila, 2024 56

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ABSTRACT: This study evaluated the antiangiogenic potential of Saccharum spontaneum (Talahib) leaf ethanolic extract using the Duck Chorioallantoic Membrane (CAM) assay, addressing the need for alternative natural therapies in angiogenesis-related diseases such as cancer. The positive control, 10 µg/mL of Ehretia microphylla (Tsaang-gubat), demonstrated a strong anti-angiogenic effect, followed by the highest dose (100% of the LC50) of the Talahib extract, while lower concentrations had weaker effects. For Average Blood Vessel Diameter (Dv), the positive control had the least value at 11.67 ± 0.97 mm, followed by the 100% concentration showing a trend of decreasing diameter with increasing concentration. The Total Blood Vessel Length (LT) saw the greatest reduction at the 75% concentration (3923.82 ± 844.99 pixels), indicating that the response is not directly proportional to concentration. Statistical analysis of LT % inhibition revealed significant differences between all concentrations of the Talahib extract and the negative control. Significant differences were also noted between the 50% and 75% groups, and between the 75% group and the positive control. The 75% concentration, identified as the most effective, likely showed significant differences in LT and LT % inhibition compared to the positive control. Phytochemical analysis confirmed the presence of bioactive compounds in the extract, supporting its anti- angiogenic potential. These results indicate that Talahib leaf ethanolic extract. particularly at the 75% concentration, exhibits notable antiangiogenic potential, with a more pronounced effect on reducing total blood vessel length rather than blood vessel diameter. Keywords: Anti-angiogenesis, cancer, plant extract, chorioallantoic membrane assay, leaf, Saccharum spontaneum

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