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In vitro anticoagulant and antiplatelet potential of citrus reticulata (var. Sagada orange) peelings and leaves crude extracts on the blood samples of albino rats (Rattus norvegicus - Wistar strain rats) 6

By: Cacho, Angelica G. Enciso, Dianne D. Fernandez, Sofia Fatima C. Magsino, Tricia Anne D. Orita, Jecca Ann A. 4 0 16, [, ] | [, ] |

Contributor(s): 5 6 [] |

Language: Unknown language code Summary language: Unknown language code Original language: Unknown language code Series: ; 4507846Edition: Description: 113 pagesContent type: text Media type: unmediated Carrier type: volumeISBN: ISSN: 2Other title: 6 []Uniform titles: | | Related works: 1 40 6 []Subject(s): -- 2 -- 0 -- -- | -- 2 -- 0 -- 6 -- | 2 0 -- | -- -- 20 -- | | -- -- -- -- 20 -- | -- -- -- 20 -- --Genre/Form: -- 2 -- Additional physical formats: DDC classification: | LOC classification: | | 2Other classification:

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Action note: In: Summary: Abstract: Coagulation is a mechanism for wound healing and early immune defense that also leads to inflammation due to fibrin deposition and maturation, as well as platelet activation, adhesion, and aggregation. Citrus species were reported to exhibit antiplatelet and anticoagulant potential as they possess secondary metabolites, specifically flavonoids and coumarins, that contribute to these properties. The objective of this study is to investigate the anticoagulant and antiplatelet activities of crude extracts from an under studied citrus plant Citrus reticulata (var. Sagada orange) leaves and peel on blood samples from albino rats (Rattus novegicus - Wistar strain rats). Using a UV-Vis spectrophotometer, the antiplatelet and anticoagulant assays were carried out. Absorbance values were processed, analyzed, and were subjected to statistical analyses. Inhibiting platelet adhesion to collagen and thrombin-induced platelet aggregation were used to measure the antiplatelet activity, whereas clotting time was used to determine the anticoagulant activity. For both assays, 25% peelings crude extract showed the most potential for antiplatelet and anticoagulant activity. Conversely, among the concentrations of the Citrus reticulata (var. Sagada orange) leaves crude extract, none exhibited anticoagulant and antiplatelet potential, both in platelet aggregation and platelet adhesion assays. These findings may be attributed to the varying presence of secondary metabolites acting on the cellular mechanisms of anticoagulant and antiplatelet properties Sagada orange. Specifically, saponins, also known to exhibit antiplatelet and anticoagulant property, were more prevalent in the extract concentration of peelings compared to flavonoids and coumarins which may be a variable that factored in with the gathered results. Keywords: Anticoagulant, Antiplatelet, Citrus reticulata, Sagada orange, Wistar strain Other editions:

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Item type	Current location	Home library	Collection	Call number	Status	Date due	Barcode	Item holds
Book	PLM	PLM Filipiniana Section	Filipiniana-Thesis	QH581 C33 2023 (Browse shelf)	Available		FT8328

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Undergraduate Thesis: (BS in Biology major in Medical Biology) - Pamantasan ng Lungsod ng Maynila, 2023 56

Abstract: Coagulation is a mechanism for wound healing and early immune defense that also leads to inflammation due to fibrin deposition and maturation, as well as platelet activation, adhesion, and aggregation. Citrus species were reported to exhibit antiplatelet and anticoagulant potential as they possess secondary metabolites, specifically flavonoids and coumarins, that contribute to these properties. The objective of this study is to investigate the anticoagulant and antiplatelet activities of crude extracts from an under studied citrus plant Citrus reticulata (var. Sagada orange) leaves and peel on blood samples from albino rats (Rattus novegicus - Wistar strain rats). Using a UV-Vis spectrophotometer, the antiplatelet and anticoagulant assays were carried out. Absorbance values were processed, analyzed, and were subjected to statistical analyses. Inhibiting platelet adhesion to collagen and thrombin-induced platelet aggregation were used to measure the antiplatelet activity, whereas clotting time was used to determine the anticoagulant activity. For both assays, 25% peelings crude extract showed the most potential for antiplatelet and anticoagulant activity. Conversely, among the concentrations of the Citrus reticulata (var. Sagada orange) leaves crude extract, none exhibited anticoagulant and antiplatelet potential, both in platelet aggregation and platelet adhesion assays. These findings may be attributed to the varying presence of secondary metabolites acting on the cellular mechanisms of anticoagulant and antiplatelet properties Sagada orange. Specifically, saponins, also known to exhibit antiplatelet and anticoagulant property, were more prevalent in the extract concentration of peelings compared to flavonoids and coumarins which may be a variable that factored in with the gathered results. Keywords: Anticoagulant, Antiplatelet, Citrus reticulata, Sagada orange, Wistar strain

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