Chelerythrine inhibits the secretory response of human blood platelets without specifically inhibiting protein kinase c 6
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Language: Unknown language code Summary language: Unknown language code Original language: Unknown language code Series: ; Taguig, Metro Manila : STII-DOST, 1997.;copyright January-March 199746Edition: Description: pp.51-61 illus.; 39 refsContent type: text Media type: unmediated Carrier type: volumeISBN: ISSN: 2Other title: 6 []Uniform titles: | | Subject(s): -- 2 -- 0 -- -- | -- 2 -- 0 -- 6 -- | 2 0 -- | -- -- 20 -- | | -- -- Protein Kinase C Medicine -- Chelerythrine -- Human Blodd Platelets -- | -- -- -- 20 -- --Genre/Form: -- 2 -- Additional physical formats: DDC classification: | LOC classification: | | 2Other classification:| Item type | Current location | Home library | Collection | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|---|---|
| Book | PLM | PLM Periodicals Section | Periodicals | Q75.P538 (Browse shelf) | Available | PER 1340CT |
ABSTRACT : Chelerythrine (chloride) has previously been documented to be a potent and selective inhibitor of the serine/threonine-specific protein kinase C (PKC). In this study, it was shown that 10 pM chelerythrine completely inhibited serotonin secretion and partially inhibited phosphatidic acid formation. In human blood platelets activated by thrombin, (1U/ml). However, there was no effect on PKC activity, as assessed by the level of phosphorylation of the 47 Kd protein. Therefore, chelerythrine has been shown not to be a specific inhibitor of PKC and without specifically affecting PKC activity, is nevertheless capable of completely inhibiting platelet secretion, indicating that it may affect the signal transductionpathway responsible for platelet secretion at a point dwostream or independent of PKC. 56
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