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In Vitro Controlled Drug Release of Anticancer Drugs Deguelin and Cisplatin by Lauric Acid Derived Polyanhydride as Carrier 6

By: 4 0 16, [, ] | [, ] |

Contributor(s): Philippine Journal of Science. 145:3 (September 2016). pp.215-223 5 6 [] |

Language: Unknown language code Summary language: Unknown language code Original language: Unknown language code Series: ; 46Edition: Description: Content type: text Media type: unmediated Carrier type: volumeISBN: ISSN: 2Other title: 6 []Uniform titles: | | Related works: 1 40 John Marty Mateo1 and Florentino C. Sumera* 6 []Subject(s): -- 2 -- 0 -- -- | -- 2 -- 0 -- 6 -- | 2 0 -- | -- -- 20 -- | | -- -- ANTICANCER;CONTROLLED DRUG RELEASE -- CISPLATIN;POLYANHYDRIDE -- -- | -- -- -- 20 -- --Genre/Form: -- 2 -- Additional physical formats: DDC classification: | LOC classification: | | 2Other classification:

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Item type	Current location	Home library	Collection	Call number	Status	Date due	Barcode	Item holds
Book	PLM	PLM Periodicals Section	Periodicals	Q75.P538 (Browse shelf)	Available		PER1922B

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ABSTRACT: New lauric acid derived polyanhydride was used in wafer form as carrier in the study of drug release of two anticancer drugs. Its degradation and drug release behavior was herein studied in phosphate buffer solution at pH 7.4 and 37o C. Anticancer drugs deguelin and cisplatin were loaded into wafers made of the new polyanhydride, poly(sebacic acid-co-hydroxylauric acid maleate) anhydride for controlled drug release studies and comparison. The polyanhydride showed that it is degradable, biocompatible and non cytotoxic. Using poly(sebacic acid-co-hydroxylauric acid maleate) anhydride wafers containing 5% deguelin, the device can provide a controlled release of deguelin in 20 days delivering 84.6% cumulative release of the drug while following a zero order model of release kinetics. Similarly the device can also provide a controlled release of cisplatin in 7 days delivering 71.22% cumulative release of the drug following also a zero order model of release kinetics. The mechanism of both drug releases was determined to be by diffusion. This drug-loaded polyanhydride system could find application in localized treatment such as in decreasing tumor size, in preventing tumor recurrence or in post-operative cancerous tumor extraction. 56

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