Astoveza, Albert Emmanuel G., Jimenez, Ysabelle Q., Molina, Kim P., Rabago, John Gabriel T., Villanueva, Irish G.  4  0   <br/><br/>
Antioxidant and radioprotective potential of ficus concinna (Red Balete) leaf methanolic crude extract on gamma-irradiated human lymphocytes        6 
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Astoveza, Albert Emmanuel G., Jimenez, Ysabelle Q., Molina, Kim P., Rabago, John Gabriel T., Villanueva, Irish G. 
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<br/><br/>   Undergraduate Thesis: (BS Biology major in Medical Biology) - Pamantasan ng Lungsod ng Maynila, 2024 
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<br/><br/> ABSTRACT:           Ficus concinna (Miq.) Miq. is a species of hemi-epiphytic strangler figs indigenous to the Philippines and other tropical and temperate areas in Asia. Its bark, roots, and leaves are ethnomedically used by the Manobo Tribe in Agusan del Sur to treat ailments. However, literature on this species is scarce despite the abundance of the phytochemicals yielded by various Ficus spp., as well as validation of their biological activity. There has been a growing interest in exploring natural sources of antioxidants and radioprotectors due to their availability and lower dose toxicity in comparison to synthetic counterparts. Thus, this study evaluated the antioxidant and radioprotective potential of F. concinna leaf methanolic crude extract. The antioxidant potential of the crude extract was assessed by its scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radicals, with absorbances measured using a microplate reader. F. concinna leaf methanolic crude extract recorded an IC50 of 93.82 μg/mL for the DPPH radical scavenging assay. On the other hand, it showed stimulating activity in the hydroxyl radical scavenging assay. The radioprotective potential was evaluated by the frequency of micronuclei, expressed as % MN, formed in gamma-irradiated human lymphocytes through the cytokinesis-block micronucleus assay. The 100% of the LC50 of F. concinna leaf methanolic crude extract was reported as the most effective concentration for the pre-treatment of human lymphocytes, with % MN of 8.863 ± 0.188%. A concentration-dependent radioprotective activity of the F. concinna leaf methanolic crude extract was also demonstrated through the inverse relationship of % MN and treatment concentrations. The results of the study demonstrated the activity of F. concinna leaf methanolic crude extract as an antioxidant and radioprotective agent. This study provides novel insights on using F. concinna for future therapeutic applications due to its antioxidant and radioprotective activity.       
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