TY  - BOOK
AU  - John Christian C. De Guzman.
AU  - 
ED  - 
ED  - 
ED  - 
ED  - 
SN  - 2
PY  - 2022///.46
CY  - 
PB  - 
KW  - 
KW  - 2
KW  - 0
KW  - 6
KW  - 20
N1  - Thesis: (Bachelor of Science in Chemistry) - Pamantasan ng Lungsod ng Maynila, 2022; 5
N2  - ABSTRACT:  	The SARS-Cov-2 RNA dependent RNA polymerase (RdRp) is the viral protein responsible for magnifying the genetic material of SARS-CoV-2, the causative agent of COVID19. Current treatment options against SARS-CoV-2 include nucleoside analog inhibitors directly interfering with the polymerase action. The nucleoside analogs pose the risk of drug resistance in long-term use. An In Silico screening and molecular docking methodology is employed in this study to examine alkaloids from the Amaryllidaceae plant family as non-nucleoside analog inhibitors of the RdRp and possess good drug-like properties and toxicity. The study identifies crinasiatine, narciprimine, pseudolycorine, lycoricidine, narciclasine, and cis-dihydronarciclasine as hit compounds against the viral protein with binding energies of -7.7, -7.4, -7.3, -7-2, and -7.1 Kcal/mol respectively. Further ADMET screening of the six hit-compounds identified lycoricidine, narciclasine, and cis-dihydronarciclasine as lead compounds with the most potential for further drug development
ER  -