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Bioactive Furanocoumarin Derivatives  from Ficus pumila (Moraceae)        6 
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<br/><br/>   ABSTRACT    The chloroform extract of Ficus pumila afforded bergapten and oxypeucedanin hydrate.  Their structures were elucidated by extensive 1D and 2D NMR spectroscopy.  The compounds were tested for antimicrobial activity against six microorganisms by the agar well method.  Bergapten was found to inhibit the growth of Staphylococcus aureus, Eschericia  coli and Salmonnella typhi, but was inactive against Trichophyton mentagrophytes, Mycobacterium pleie and Candida albicans.    Oxypeucedanin hydrate inhibited  the growth of Salmonella typhi, but was found inactive against the other five microorganisms.  Both compounds were also tested for antimutagenic activity by the use of the micronucleus test.  Results of the study polychromatic (MPCE) induced by mitomycin C by 44%, while oxypeucedanin hydrate reduced MPCE by 74%. 
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<br/><br/><label>Subjects--Topical Terms: </label><br/>Chemistry;Ficus Pumila    ------Bioactive Furanocoumarin Derivatives;Antimocrobial--Antimutagen--
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