Chelerythrine inhibits the secetory response of human blood platelets without specifically inhibiting protein kinase c. 6
By: 4 0 16 [, ] | [, ] |
Contributor(s): Lane, Trevor 5 6 [Novales-Li, Philipp] |
Language: Unknown language code Summary language: Unknown language code Original language: Unknown language code Series: ; Taguig, Metro Manila : STII-DOST, 197746Edition: Description: illus.; 39 refsContent type: text Media type: unmediated Carrier type: volumeISBN: ISSN: 2Other title: 6 []Uniform titles: | | Subject(s): -- 2 -- 0 -- -- | -- 2 -- 0 -- 6 -- | 2 0 -- | -- -- 20 -- | | -- -- Chelerythrine -- Human Blood Platelets -- Protein Kinase C. -- | -- -- -- 20 -- --Genre/Form: -- 2 -- Additional physical formats: DDC classification: | PJS 3 LOC classification: | | 2Other classification:| Item type | Current location | Home library | Collection | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|---|---|
| Book | PLM | PLM Periodicals Section | Periodicals | Q75.P538 (Browse shelf) | Available | PER 1340CI |
ABSTRACT : In this study , it was shown that 10 uM chelerythrine completely inhibited serotonim secretion and partially inhibited phosphatidic acid formation, in humanblood platelets activated by thrombin. (1 U/ml). However, there was no effect on PKC activity, as assessed by the level of phosphorylation of the 47 Kd protein. Therefore chelerythrine has been shown not to be a specific inhibitor of PKC and without specifically affecting PKC activity, is nevertheless capable of completely inhibiting platelet secretion, indicating that it may affect the signal transduction pathway responsible for platelet secretion at a point downstream or independent of PKC. 56
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