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100			_e _e _aDarnell, James E. _d _b4 _u _c0 _q16
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245		0	_a _aMolecular cell biology / _d _b _n _cJames Darnell, Harvey Lodish, David Baltimore. _h6 _p
246			_a _a _b _n _i _f6 _p
249			_i _i _a
250			_6 _6 _aSecond edition. _b
260			_e _e _a _b _f _c _g
264			_3 _3 _aNew York : _d _bScientific American Books :;Distributed by W.H. Freeman, _c[1990];copyright 199046
300			_e _e _c28 cm. _axl, 1105 pages : _billustrations (some color)
310			_a _a _b
321			_a _a _b
336			_b _atext _2rdacontent
337			_3 _30 _b _aunmediated _2rdamedia
338			_3 _30 _b _avolume _2rdacarrier
340			_2 _20 _g _n
344			_2 _2 _a0 _b
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362			_a _a _b
385			_m _m _a2
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440			_p _p _a _x _v
490			_a _a _x _v
500			_a _a _d _b _c56
504			_a _aIncludes bibliographical references and index. _x
505			_a _aIntroduction: The history of molecular cell biology. Evolution and the cell theory -- Classical biochemistry and genetics -- The merging of genetics and biochemistry -- The birth of molecular biology -- A modern view of cell structure -- Part I. Molecules, cells, proteins, and experimental techniques: a primer. [Ch.1] Chemical foundations -- Energy -- Chemical bonds -- Chemical equilibrium -- Ph and the concentration of hydrogen ions -- The direction of chemical reactions -- Activation energy and reaction rate -- [Ch.2] Molecules in cells proteins -- Enzymes -- Antibodies -- Nucleic acids -- DNA -- Lipids and biomembranes -- Carbohydrates -- The primacy of proteins -- [Ch.3] Synthesis of proteins and nucleic acids -- Rules for the synthesis of proteins and nucleic acids -- Protein synthesis: the three roles of RNA -- The steps in protein synthesis -- Nucleic acid synthesis -- [Ch.4] The study of cell organization and subcellular structure -- Prokaryotic and eukaryotic cells -- Light microscopy and cell architecture -- Electron microscopy -- Sorting cells and their parts -- The organelles of the eukaryotic cells -- [Ch.5] Growing and manipulating cells and viruses -- Types of cell division -- The cell cycle in prokaryotes consists of DNA replication followed immediately by cell division -- Eukaryotic DNA synthesis occurs in a special phase of the cell cycle -- The growth of microorganisms and cells in culture -- Cell fusion: an important technique in somatic-cell genetics -- DNA transfer into eukaryotic cells -- Viruses: structures and function.;[Ch.6] Manipulating macromolecules -- Radioisotopes: the indispensible modern means of following biological activity -- Determining the size of nucleic acids and proteins -- Examining the sequences of nucleic acids and proteins -- Recombinant DNA: selection and production of specific DNA -- Controlled deletions and base-specific mutagenesis of DNA -- Synthetic peptide and nucleotide sequences: their use in isolating and identifying genes -- Part II. Gene expression, structure, and replication -- [Ch.7] RNA synthesis and gene control in prokaryotes -- Overall strategy of prokaryotic gene control -- Control of transcriptional initiation -- Negative control of transcription: the lactose operon -- Positive control of transcription: the arabinose operon -- Compound control of transcription -- Control of regulatory proteins -- Control of transcriptional termination -- Bacteriophage a infection: alternative physiologic states determined by a complex transcriptional control program -- Global control in E. Coli -- Stability of biopolymers in bacterial cells -- [Ch.8] RNA synthesis and processing in eukaryotes -- Relationship of nuclear and cytoplasmic RNA -- Function and structure of RNA polymerases -- Three methods for mapping transcription units -- Synthesis and processing of Pre-rRNA -- Synthesis and processing of 5S rRNA and tRNAs -- Synthesis and processing of mRNAs: general pathway -- Transcription of mRNA genes by RNA polymerase II -- Conversion of hnRNA to mRNA -- Variations on the splicing theme, including self-splicing -- mRNAs may be directed toward specific cytoplasmic sites.;[Ch.9] The structure of eukaryotic chromosomes -- Morphology and functional elements of eukaryotic chromosomes -- Structure of chromatin -- Biologic definitions of a gene -- Molecular definition of a gene -- [Ch.10] Eukaryotic chromosomes and genes: molecular anatomy -- Major classes of eukaryotic DNA -- Solitary protein-coding genes -- Duplicated protein-coding genes -- Tandemly repeated genes encoding rRNA, tRNA, and histones -- Repetitious DNA fractions -- Simple-sequence DNA -- Intermediate repeat DNA and mobile DNA elements -- Functional rearrangements in chromosomal DNA -- [Ch.11] Gene control and the molecular genetics of development in eukaryotes -- The purpose of gene control in unicellular versus multicellular organisms -- Variations in proteins among cell types -- The three components of gene control: signals, levels, and mechanisms -- Signals for gene control -- Experimental demonstration of transcriptional control -- Structure and function of DNA-binding proteins that regulate transcription of protein-coding genes -- Transcriptional control of yeast cell specificity -- Gene control in animal cells -- Control of regulatory-protein activity and possible effects of chromatin structure on gene activity -- Control of transcriptional termination -- Differential processing of pre-mRNA -- Overlapping transcription units: transcriptional control not processing control -- Regulation of ribosomal RNA -- Cytoplasmic control of gene expression.;[Ch.12] DNA replication, repair, and recombination -- General features of DNA synthesis and replication -- Initiation and propagation of a DNA chain at a growing fork -- Topoisomerases and superhelicity in DNA -- Assembly of DNA into nucleosomes -- Repair of DNA -- Recombination between homologous DNA sites -- Part III. Cell structure and function -- [Ch.13] The plasma membrane -- The architecture of lipid membranes -- Membrane proteins -- Principles of membrane organization -- The erythrocyte membrane: cytoskeletal attachment -- Specialized regions of the plasma membrane -- Types of cell junctions -- [Ch.14] Transport across cell membranes -- Passive transport across the cell membrane -- Ion channels, intracellular ion environment, and membrane electric potential -- Active ion transport and ATP hydrolysis -- Cotransport: symport and antiport -- Transport into prokaryotic cells -- Osmosis, movement of water, and the regulation of cell volume -- The internalization of macromolecules and particles -- Receptor-mediated endocytosis -- Entry of viruses and toxins into cells -- [Ch.15] Energy conversion: the formation of ATP in mitochondria and bacteria -- Energy metabolism in the cytosol -- Mitochondria and the metabolism of carbohydrates and lipids -- The proton-motive force, ATP generation, and transport of metabolite closed vesicles are required for the generation of ATP -- NADH, electron transport, and proton pumping -- Metabolic regulation --;[Ch.16] Photosynthesis -- An overview of photosynthesis in plants -- The light-absorbing steps of photosynthesis -- Molecular analysis of bacterial photosynthesis -- The structure and function of the two plant photosystems: PSI and PSII -- CO2 metabolism during photosynthesis -- [Ch.17] Plasma-membrane, secretory, and lysosome proteins: biosynthesis and sorting -- The synthesis of membrane lipids -- Sites of organelle- and membrane-protein synthesis -- Overall pathway for the synthesis of secretory and membrane proteins -- The transport of secretory and membrane proteins into or across the ER membrane -- Posttranslational modifications of secretory and membrane proteins in the rough -- Golgi vesicles: sorting and glycosylation of secretory and membrane proteins -- Golgi and post-golgi sorting and processing of secretory and membrane proteins -- [Ch.18] Organelle biogenesis: the nucleus, chloroplast, and mitochondrion -- Assembly and disassembly of the nuclear membrane -- Protein import into the cell nucleus -- Mitochondrial DNA: structure, expression, and variability Synthesis and localization of mitochondrial proteins -- Chioroplast DNA and biogenesis of plastids -- [Ch.19] Cell-to-cell signaling: hormones and receptors -- The role of extracellular signals in cellular metabolism -- Identification and purification of cell- surface receptors -- Epinephrine receptors and the activation of adenylate cyclase -- cAMP and regulation of cellular metabolism -- Ca2+ ions, inositol phosphates, and 1,2- diacylglycerol as second messengers -- Insulin and glucagon: hormone regulation of blood glucose levels -- Receptor regulation -- Hormones and cell-to-cell signaling in microorganisms -- Plant hormones and plant growth and differentiation.;[Ch.20] Nerve cells and the electric properties of cell membranes -- Neurons, synapses, and nerve circuits -- The action potential and conduction of electric impulses -- Molecular properties of voltage-gated ion channel proteins -- Synapses and impulse transmission -- Synaptic transmission and the nicotinic acetylcholine receptor -- Functions of other neurotransmitters and their receptors -- Memory and neurotransmitters -- Sensory transduction: the visual system -- [Ch.21] Microtubules and cellular movements -- Structure and diversity of microtubules -- Structural and kinetic polarity of microtubules --
505			_aHeterogenity of a- and b-tubulin -- Intracellular transport via microtubules -- Cilia and flagella: structure and movement -- Basal bodies and centrioles: structure and properties -- Function of microtubules in mitosis -- [Ch.22] Actin, myosin, and intermediate filaments: cell movements and cell shape -- Actin and myosin filaments -- Muscle structure and function -- Actin and myosin in nonmuscle cells -- Intermediate filaments -- [Ch.23] Multicellularity: cell-cell and cell-matrix interactions -- The extracellular matrix serves many functions -- Collagen: a class of multifunctional fibrous proteins -- Hyaluronic acid and proteoglycans -- Laminin, fibronectin, and other multiadhesive matrix glycoproteins -- Cell-cell adhesion proteins -- Cell and matrix interactions during development -- Cell and matrix interactions during neuron development -- Structure and function of the plant cell wall -- Part IV. The new biology: facing classic questions at the frontier.;[Ch. 24] Cancer characteristics of tumor cells -- Use of cell cultures in cancer research -- DNA viruses as transforming agents -- RNA-containing retroviruses as transforming agents -- Human tumor viruses -- Chemical carcinogens -- The role of radiation and DNA repair in carcinogenesis -- Oncogenes and their proteins: classification and characteristics -- The role of cellular oncogenes in carcinogenesis -- The multicausal, multistep nature of carcinogenesis -- Human cancer -- [Ch.25] Immunity -- Overview -- Antibodies and the generation of diversity -- The antigen-independent phase of b-lymphocyte maturation T lymphocytes -- The antigen-dependent phase of the immune response -- [Ch.26] Evolution of cells -- Prebiotic synthesis -- RNA catalysis: a basis for a precellular genetic system? -- A reconstructive analysis of cell lineages -- Evolution of gene structure: lessons from present-day intron distributions. _b _t _g _r
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650			_x _x _aCytology.;Molecular biology.;Cells.;Molecular Biology. _d _b _z _y20 _v
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700			_i _i _t _c _b _s1 _q _f _k40 _p _d _e _aLodish, Harvey F.;Baltimore, David. _l _n6
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