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_aRoy G. Vincoy,Benedicto dl Carpio, Eileen Rgalado-Morales, Armelia Lapitan-Torres.
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245 0 _a
_aEfficacy and Safety of 5.0% Sodium Hypochloride in the treatment of Molluscum Contagiosum : a double blind, placebo-controlled, randomized clinical trial.
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_aunmediated
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_avolume
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_aABSTRACT : Introduction : Molluscum Contagiosum is a disease common in children. No single treatment is uniformly effective. 5% Sodium hypochlorite has an irritant properly that may induce inflammation. Objective : To determine the efficacy and safety of 5% Sodium Hypochlorite in the treatment of Molluscum Contagiosum. Methods : The study was a randomized, double blind controlled clinical trial conducted from May 2012 to October 2012 in the Department of Dermatology in Ospital ng Maynila Medical center. Sixteen patients were enrolled and randomly allocated using sealed opaque coded paper to apply 5% Sodium hypochloride solution (n=9) or placebo (n=7) twice daily for 4 weeks. Two hundred lesions were included in the study, 137 in experimental group and 63 in placebo group.The investigator and the patients were blinded tot he treatment allocation. Clinical parameters of inflammation (erthema) and resolution were noted at Weeks 1 to 4. Results : Demographic characteristics showed no statistical difference (p.0.05). Significantly, more lesions resolved at week 4 (18/137, p = 0.02) and higher percentage of resolution at weeks 2 to 4 were noted in the experimental group with p-values of 0.05, 0.01 and 0.02 respectively. This was reflected in the comnparison in achieving a reaction (erthema and resolution). Significant differtence was noted as to the percentage of reaction at weeks 1 to 4 (p=0.02,0.01,0.05 and0.001). As to the number of lesions, there was a significant difference at Weeks 1 (8/137, 6%) and week 4 (30/137,22%) (p=0.05 and 0.002). Mild pruritus was associated with erythema. Two out of seven subjects in placebo group reportedappearance of new lesions.
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_xSodium Hypochlorite;Randomized Clinical Tiral
_aMolluscum contagiosum
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