000 04189nam a2201261Ia 4500
000 02404cam a2200409Mi 4500
001 81041
003 0
005 20250920171856.0
006 m d
007 cr |||||||||||
008 180601s2018 xxk fo 000 0 eng d
010 _z
_z
_o
_a
_b
015 _22
_a
016 _2
_2
_a
_z
020 _e
_e
_a9781118874905
_b
_z
_c
_qelectronic book : oBook
_x
022 _y
_y
_l
_a2
024 _2
_2
_d
_c
_a
_q
028 _a
_a
_b
029 _a
_a
_b
032 _a
_a
_b
035 _a
_a(OCoLC)1052001616;(OCoLC)on1052001616
_b
_z
_c
_q
037 _n
_n
_c
_a9781118874936
_bWiley
040 _e
_erda
_aNLE
_dDG1;OCLCF
_beng
_cNLE
041 _e
_e
_a
_b
_g
_h
_r
043 _a
_a
_b
045 _b
_b
_a
049 _aMAIN
050 _a
_aR853.C55
_d
_b2
_c0
051 _c
_c
_a
_b
055 _a
_a
_b
060 _a
_a
_b
070 _a
_a
_b
072 _2
_2
_d
_a
_x
082 _a
_a615.5072/4
_d
_b223
_c
084 _2
_2
_a
086 _2
_2
_a
090 _a
_a
_m
_b
_q
092 _f
_f
_a
_b
096 _a
_a
_b
097 _a
_a
_b
100 _e
_eauthor.
_aMachin, David,
_d
_b4
_u
_c0
_q16
110 _e
_e
_a
_d
_b
_n
_c
_k
111 _a
_a
_d
_b
_n
_c
130 _s
_s
_a
_p
_f
_l
_k
210 _a
_a
_b
222 _a
_a
_b
240 _s
_s
_a
_m
_g
_n
_f
_l
_o
_p
_k
245 0 _a
_aSample sizes for clinical, laboratory and epidemiology studies /
_d
_b
_n
_cDavid Machin, Michael J. Campbell, Say-Beng Tan, Sze-Huey Tan.
_h6
_p
246 _a
_a
_b
_n
_i
_f6
_p
249 _i
_i
_a
250 _6
_6
_aFourth edition.
_b
260 _e
_e
_a
_b
_f
_c
_g
264 _3
_3
_aHoboken, NJ :
_d
_bWiley-Blackwell,
_c[2018]46
300 _e
_e
_c
_a1 online resource (400 pages).
_b
310 _a
_a
_b
321 _a
_a
_b
336 _b
_atext
_2rdacontent
337 _3
_30
_b
_acomputer
_2rdamedia
338 _3
_30
_b
_aonline resource
_2rdacarrier
340 _2
_20
_g
_n
344 _2
_2
_a0
_b
347 _2
_2
_a0
362 _a
_a
_b
385 _m
_m
_a2
410 _t
_t
_b
_a
_v
440 _p
_p
_a
_x
_v
490 _a
_a
_x
_v
500 _a
_aPreface vii 1 Basic Design Considerations 1 2 Further Design Considerations 29 3 Binary Outcomes 41 4 Ordered Categorical Outcomes 55 5 Continuous Outcomes 67 6 Rate Outcomes 81 7 Survival Time Outcomes 97 8 Paired Binary, Ordered Categorical and Continuous Outcomes 115 9 Confidence Intervals 135 10 Repeated Outcome Measures 155 11 Non?]Inferiority and Equivalence 167 12 Cluster Designs 193 13 Stepped Wedge Designs 211 14 More than Two Groups Designs 225 15 Genomic Targets and Dose?]Finding 235 16 Feasibility and Pilot Studies 247 17 Therapeutic Exploratory Trials: Single Arm with Binary Outcomes 265 18 Therapeutic Exploratory Trials: Survival, Dual Endpoints, Randomised and Genomic Targets 281 19 The Correlation Coefficient 303 20 Observer Agreement Studies 315 21 Reference Intervals and Receiver Operating Curves 337 22 Sample Size Software 359 Cumulative References 361 Index
_d
_b
_c56
504 _a
_a
_x
505 _a
_a
_b
_t
_g
_r
506 _a
_a5
510 _a
_a
_x
520 _b
_b
_c
_a
_u
521 _a
_a
_b
533 _e
_e
_a
_d
_b
_n
_c
540 _c
_c
_a5
542 _g
_g
_f
546 _a
_a
_b
583 _5
_5
_k
_c
_a
_b
590 _a
_a
_b
600 _b
_b
_v
_t
_c2
_q
_a
_x0
_z
_d
_y
610 _b
_b
_v
_t2
_x
_a
_k0
_p
_z
_d6
_y
611 _a
_a
_d
_n2
_c0
_v
630 _x
_x
_a
_d
_p20
_v
648 _2
_2
_a
650 _x
_xStatistical methods.
_aClinical trials;Sampling (Statistics).
_d
_b
_z
_y20
_v
651 _x
_x
_a
_y20
_v
_z
655 _0
_0
_aElectronic books.
_y2
_z
700 _i
_i
_t
_c
_b
_s1
_q
_f
_k40
_p
_d
_eauthor.;author.;author.
_aCampbell, Michael J.,;Tan, Say Beng,;Tan, Sze Huey,
_l
_n6
710 _b
_b
_t
_c
_e
_f
_k40
_p
_d5
_l
_n6
_a
711 _a
_a
_d
_b
_n
_t
_c
730 _s
_s
_a
_d
_n
_p
_f
_l
_k
740 _e
_e
_a
_d
_b
_n
_c6
753 _c
_c
_a
767 _t
_t
_w
770 _t
_t
_w
_x
773 _a
_a
_d
_g
_m
_t
_b
_v
_i
_p
775 _t
_t
_w
_x
776 _s
_s
_a
_d
_b
_z
_i
_t
_x
_h
_c
_w
780 _x
_x
_a
_g
_t
_w
785 _t
_t
_w
_a
_x
787 _x
_x
_d
_g
_i
_t
_w
800 _a
_a
_d
_l
_f
_t0
_q
_v
810 _a
_a
_b
_f
_t
_q
_v
830 _x
_x
_a
_p
_n
_l0
_v
942 _a
_alcc
_cBK
999 _c20887
_d20887