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_aJotham B. Naval Matthew Mark A. Martinez Janiz Alyna A. Ramos Frances Anne DR. Salazar Kim Colline Enriquez
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_aIn-vitro anthelmintic potential of strongylodon macrobotrys (Tayabak) and dillenia philippinensis (Katmon) methanol leaf extract against caenorhabditis elegans
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_a92 pages
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_aUndergraduate Thesis: (Bachelor of Science in Biology) - Pamantasan ng Lungsod ng Maynila, 2023
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_aABSTRACT: Infections caused by soil-transmitted helminths continue to be a common and prevalent health concern in the world. Herbal plants are utilized as alternatives to synthetic study anthelmintics since these drugs are sometimes subject to anthelmintic resistance. The was designed to examine the anthelmintic potential among the varying concentrations (0.2, 0.6, 0.8, 1.0, and 2.0 mg/mL) of Strongylodon macrobotrys and Dillenia philippinensis methanolic leaf extracts using Caenorhabditis elegans as the model species for soil-transmitted helminths. These concentrations were administered to the plates containing C. elegans to examine the mortality index and larval development of the free-living nematode. Results indicated that for 24 hours, both S. macrobotrys (95.83% mortality) and concentration, while for 48 hours best concentration of S. macrobotrys was 2.0 mg/mL ớ To a ong philippinensis (85.42% mortality) had 2.0 mg/mL as the best (100.00% mortality) while D. philippinensis' best concentration was 0.8 mg/mL 96.02% mortality) in terms of mortality. Larval development assay also reported anthelmintic properties with the lowest percentage being greater L4-adult stage percent compared to the M9 buffer (45.45% > 12.5%). Statistical analysis through ANOVA showed that there are no significant differences among the varying concentrations of both S. macrobotrys (0.23 > 0.05 at 24-hr and 48-hr) and D. philippinensis (0.73 > 0.05 at 24-hr; 0.63 > 0.05 at 48-hr), as well as between the most effective concentrations in 24-hr (0.71 > 0.05) and 48-hr (0.08 > 0.05) post-treatment.
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