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_e _e _aCacho, Angelica G. Enciso, Dianne D. Fernandez, Sofia Fatima C. Magsino, Tricia Anne D. Orita, Jecca Ann A. _d _b4 _u _c0 _q16 |
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_a _aIn vitro anticoagulant and antiplatelet potential of citrus reticulata (var. Sagada orange) peelings and leaves crude extracts on the blood samples of albino rats (Rattus norvegicus - Wistar strain rats) _d _b _n _c _h6 _p |
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_b _atext _2rdacontent |
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_3 _30 _b _aunmediated _2rdamedia |
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_3 _30 _b _avolume _2rdacarrier |
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_a _aUndergraduate Thesis: (BS in Biology major in Medical Biology) - Pamantasan ng Lungsod ng Maynila, 2023 _d _b _c56 |
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_b _b _c _aAbstract: Coagulation is a mechanism for wound healing and early immune defense that also leads to inflammation due to fibrin deposition and maturation, as well as platelet activation, adhesion, and aggregation. Citrus species were reported to exhibit antiplatelet and anticoagulant potential as they possess secondary metabolites, specifically flavonoids and coumarins, that contribute to these properties. The objective of this study is to investigate the anticoagulant and antiplatelet activities of crude extracts from an under studied citrus plant Citrus reticulata (var. Sagada orange) leaves and peel on blood samples from albino rats (Rattus novegicus - Wistar strain rats). Using a UV-Vis spectrophotometer, the antiplatelet and anticoagulant assays were carried out. Absorbance values were processed, analyzed, and were subjected to statistical analyses. Inhibiting platelet adhesion to collagen and thrombin-induced platelet aggregation were used to measure the antiplatelet activity, whereas clotting time was used to determine the anticoagulant activity. For both assays, 25% peelings crude extract showed the most potential for antiplatelet and anticoagulant activity. Conversely, among the concentrations of the Citrus reticulata (var. Sagada orange) leaves crude extract, none exhibited anticoagulant and antiplatelet potential, both in platelet aggregation and platelet adhesion assays. These findings may be attributed to the varying presence of secondary metabolites acting on the cellular mechanisms of anticoagulant and antiplatelet properties Sagada orange. Specifically, saponins, also known to exhibit antiplatelet and anticoagulant property, were more prevalent in the extract concentration of peelings compared to flavonoids and coumarins which may be a variable that factored in with the gathered results. Keywords: Anticoagulant, Antiplatelet, Citrus reticulata, Sagada orange, Wistar strain _u |
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