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_aBioactive Furanocoumarin Derivatives from Ficus pumila (Moraceae)
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246 _a
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_aManila : STII-DOST, 1997
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_aunmediated
_2rdamedia
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_avolume
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_aABSTRACT The chloroform extract of Ficus pumila afforded bergapten and oxypeucedanin hydrate. Their structures were elucidated by extensive 1D and 2D NMR spectroscopy. The compounds were tested for antimicrobial activity against six microorganisms by the agar well method. Bergapten was found to inhibit the growth of Staphylococcus aureus, Eschericia coli and Salmonnella typhi, but was inactive against Trichophyton mentagrophytes, Mycobacterium pleie and Candida albicans. Oxypeucedanin hydrate inhibited the growth of Salmonella typhi, but was found inactive against the other five microorganisms. Both compounds were also tested for antimutagenic activity by the use of the micronucleus test. Results of the study polychromatic (MPCE) induced by mitomycin C by 44%, while oxypeucedanin hydrate reduced MPCE by 74%.
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_aChemistry;Ficus Pumila
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_zBioactive Furanocoumarin Derivatives;Antimocrobial
_yAntimutagen
_2sears;sears0
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651 _x
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_aErlinda A. Juan, John A. Rideout and Consolacion Y. Ragasa
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710 _b
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_aPhilippine Journal of Science 126 (2) : April - June 1997. pp. 143-153
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