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Antigenotoxicity of virgin coconut oil as determined by micronucleus test. 6

By: Cruz, Jelarmi R. 4 0 16, [, ] | [, ] |

Contributor(s): 5 6 [] |

Language: Unknown language code Summary language: Unknown language code Original language: Unknown language code Series: ; February 2005.46Edition: Description: 28 cm. vii,38 ppContent type: text Media type: unmediated Carrier type: volumeISBN: ISSN: 2Other title: 6 []Uniform titles: | | Related works: 1 40 6 []Subject(s): -- 2 -- 0 -- -- | -- 2 -- 0 -- 6 -- | 2 0 -- | -- -- 20 -- | | -- -- -- -- 20 -- | -- -- -- 20 -- --Genre/Form: -- 2 -- Additional physical formats: DDC classification: | LOC classification: | | 2Other classification:

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Action note: In: Summary: ABSTRACT: This research was done to determine the antigenotoxic potential of Virgin Coconut Oil against the genotoxin tetracycline on the bone marrow cells of white mice (Mus musculus). Micronucleus test developed by Schmidt was the protocol used by counting the formation of micronucleated polychromatic erythrocytes against the normal polychromatic erythrocytes. Twenty-four healthy white mice were used as the test animals. The test system composed of tetracycline, positive control and the virgen coconut oil that were administered by Intraperitoneal and by oral gavage. The treatments were given twenty-four (24) hours apart. The mice were sacrificed by cervical disclocation 6 hours after last administration. The femurs were dissected and the bone marrow flushed, centrifuged and smeared. The formation of micronucleus were counted in the well spread and undamaged regions of the spread and undamaged regions of the prepared slides. Results of the study show that Virgen Coconut Oil which was administered for a week showed the best antigenotoxic potential. It is followed by the positive control group and the virgin coconut oil administered for a day. There is no significant difference when the virgin coconut oil was administered in different time interval. Other editions:

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Item type	Current location	Home library	Collection	Call number	Status	Date due	Barcode	Item holds
Book	PLM	PLM Filipiniana Section	Filipiniana-Thesis	T QR194.An58.C78.2005 (Browse shelf)	Available		FT7632

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Thesis:(B.S. Biology)- Pamantasan ng Lungsod ng Maynila,2005. 56

ABSTRACT: This research was done to determine the antigenotoxic potential of Virgin Coconut Oil against the genotoxin tetracycline on the bone marrow cells of white mice (Mus musculus). Micronucleus test developed by Schmidt was the protocol used by counting the formation of micronucleated polychromatic erythrocytes against the normal polychromatic erythrocytes. Twenty-four healthy white mice were used as the test animals. The test system composed of tetracycline, positive control and the virgen coconut oil that were administered by Intraperitoneal and by oral gavage. The treatments were given twenty-four (24) hours apart. The mice were sacrificed by cervical disclocation 6 hours after last administration. The femurs were dissected and the bone marrow flushed, centrifuged and smeared. The formation of micronucleus were counted in the well spread and undamaged regions of the spread and undamaged regions of the prepared slides. Results of the study show that Virgen Coconut Oil which was administered for a week showed the best antigenotoxic potential. It is followed by the positive control group and the virgin coconut oil administered for a day. There is no significant difference when the virgin coconut oil was administered in different time interval.

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