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Synergistic anti-angiogenic effect of maidenhair tree (Ginkgo biloba L.) and sabah snake grass (Clinicanthus nutans Burm F. Lindau) leaf crude methanolic extract on chick embryo in ovo chorioallantoic membrane (CAM) assay De Guzman, Ramon Carlos R., Plete, Rianne Victoria C., Siruno, Alleah Nicole S. 6

By: De Guzman, Ramon Carlos R., Plete, Rianne Victoria C., Siruno, Alleah Nicole S. 4 0 16, [, ] | [, ] |

Contributor(s): 5 6 [] |

Language: Unknown language code Summary language: Unknown language code Original language: Unknown language code Series: ; 4544446Edition: Description: 165 pagesContent type: text Media type: unmediated Carrier type: volumeISBN: ISSN: 2Other title: 6 []Uniform titles: | | Related works: 1 40 6 []Subject(s): -- 2 -- 0 -- -- | -- 2 -- 0 -- 6 -- | 2 0 -- | -- -- 20 -- | | -- -- -- -- 20 -- | -- -- -- 20 -- --Genre/Form: -- 2 -- Additional physical formats: DDC classification: | LOC classification: | | 2Other classification:

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Action note: In: Summary: ABSTRACT: The study investigated the synergistic anti-angiogenic activity of maidenhair tree (Ginkgo biloba L.) and Sabah snake grass (Clinacanthus nutans Burm f. Lindau) leaf crude methanolic extract utilizing chick embryos via in ovo chorioallantoic membrane assay. Brine shrimp lethality assay was utilized to get the median lethal concentration or LC50 of the experimental treatments. For quantitative analysis, Fiji/ImageJ software was employed. The study employs both macroscopic evaluation using a Semi-Quantitative Scoring System and quantitative analysis via Fiji/ImageJ software to measure vessel length and vessel diameter, to further assess synergistic and antagonistic interactions of the combination extract across different concentrations. Results indicate a synergistic effect at 100% concentration, notably reducing average total vessel length, while antagonistic interactions are observed concerning average vessel diameter. G. biloba alone demonstrates significant anti-angiogenic effects, particularly at higher concentrations, attributed to the presence of phytochemicals inhibiting angiogenic pathways. Semi-quantitative evaluation suggests strong anti-angiogenic effects for the 1:1 combination at 25% concentration, albeit potentially influenced by human error and bias upon comparison with the positive control Bevacizumab which yielded non-statistically significant results. The findings underscore the potent anti-angiogenic potential of G. biloba, especially at higher concentrations, while the 1:1 combination showed concentration-dependent responses, meriting further exploration for therapeutic applications. Addressing limitations and pursuing future research directions outlined herein can advance the development of novel anti-angiogenic agents and explore synergistic combinatory therapies. Other editions:

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Item type	Current location	Home library	Collection	Call number	Status	Date due	Barcode	Item holds
Book	PLM	PLM Filipiniana Section	Filipiniana-Thesis	QH581 D44 2024 (Browse shelf)	Available		FT8424

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Undergraduate Thesis: (BS Biology major in Medical Biology) - Pamantasan ng Lungsod ng Maynila, 2024 56

ABSTRACT: The study investigated the synergistic anti-angiogenic activity of maidenhair tree (Ginkgo biloba L.) and Sabah snake grass (Clinacanthus nutans Burm f. Lindau) leaf crude methanolic extract utilizing chick embryos via in ovo chorioallantoic membrane assay. Brine shrimp lethality assay was utilized to get the median lethal concentration or LC50 of the experimental treatments. For quantitative analysis, Fiji/ImageJ software was employed. The study employs both macroscopic evaluation using a Semi-Quantitative Scoring System and quantitative analysis via Fiji/ImageJ software to measure vessel length and vessel diameter, to further assess synergistic and antagonistic interactions of the combination extract across different concentrations. Results indicate a synergistic effect at 100% concentration, notably reducing average total vessel length, while antagonistic interactions are observed concerning average vessel diameter. G. biloba alone demonstrates significant anti-angiogenic effects, particularly at higher concentrations, attributed to the presence of phytochemicals inhibiting angiogenic pathways. Semi-quantitative evaluation suggests strong anti-angiogenic effects for the 1:1 combination at 25% concentration, albeit potentially influenced by human error and bias upon comparison with the positive control Bevacizumab which yielded non-statistically significant results. The findings underscore the potent anti-angiogenic potential of G. biloba, especially at higher concentrations, while the 1:1 combination showed concentration-dependent responses, meriting further exploration for therapeutic applications. Addressing limitations and pursuing future research directions outlined herein can advance the development of novel anti-angiogenic agents and explore synergistic combinatory therapies.

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